AB1320 DOPPLER ULTRASOUND IN GIANT CELL ARTERITIS: WHICH TERRITORIES SHOULD WE EXPLORE? A RETROSPECTIVE ANALYSIS OF A SINGLE CENTER EXPERIENCE (2024)

AB1320 DOPPLER ULTRASOUND IN GIANT CELL ARTERITIS: WHICH TERRITORIES SHOULD WE EXPLORE? A RETROSPECTIVE ANALYSIS OF A SINGLE CENTER EXPERIENCE (1)

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  • AB1320 DOPPLER ULTRASOUND IN GIANT CELL ARTERITIS: WHICH TERRITORIES SHOULD WE EXPLORE? A RETROSPECTIVE ANALYSIS OF A SINGLE CENTER EXPERIENCE

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Vasculitis, large vessels including polymyalgia rheumatica

AB1320 DOPPLER ULTRASOUND IN GIANT CELL ARTERITIS: WHICH TERRITORIES SHOULD WE EXPLORE? A RETROSPECTIVE ANALYSIS OF A SINGLE CENTER EXPERIENCE

  1. L. Pérez Gallego1,
  2. M. Mascaró Pol1,
  3. J. Mestre Torres1,
  4. R. Solans-Laqué1,
  5. F. Martínez-Valle1,
  6. A. Guillen-Del-Castillo1,
  7. A. Valls Villalba1,
  8. I. Sanz Pérez1
  1. 1Hospital Universitari Vall d’Hebron, Internal Medicine, Barcelona, Spain

Abstract

Background: Giant cell arteritis (CGA) can be a disabling disease, with permanent vision loss as a severe complication in untreated patients. The use of temporal and axillary Doppler ultrasound (DUS) has changed how we evaluate our patients, reducing the need for invasive techniques such as temporal artery biopsy (TAB).

Objectives: The aim of this study is to describe the use of DUS performed by internal medicine physicians to diagnose GCA.

Methods: Observational retrospective study that included all patients evaluated at a DUS clinic under a GCA diagnosis between 05/21 and 05/23. Information about symptoms, blood tests, DUS and PET/CT was registered. Patients were classified as low GCA suspicion, high GCA suspicion, polymyalgia rheumatica (PMR) diagnosis. DUS was considered positive if a hypoechoic arterial wall thickening was observed in temporal (TA), carotid (CA), vertebral (VA) or axillary (AxA) arteries. PET/CT was considered positive if vascular wall uptake was higher than liver uptake. Aorta, supraaortic branches and vertebral arteries (VA) were evaluated. A definite diagnosis was made if ACR/EULAR 2022 classification criteria were met. Analisis was performed by SPSS v20. Results are expressed as mean ± standard deviation or median (quartile 1 – quartile 3). Univariate analysis was initially performed, and significance was set at p<0.05. 95% confidence intervals are expressed. Logistic regression was finally evaluated.

Results: We evaluated 119 patients, 78 (65.5%) women, with a medium age of 81±15 years. 52 patients (43.7%) met ACR/EULAR 2022 criteria for GCA diagnosis. DUS was positive in 45 (37.8%) patients: 5 (25%) in the PMR group, 14 (23%) in the low probability and 25 (65.8%) in the high probability group. The distribution of DUS findings included an abnormality in 28 TA, 5 CA, 4 VA and 12 AxA. 2 patients had a TA and AxA abnormality. One patient with CA involvement showed a TA halo sign. Four patients had VA involvement, 3 of them with an abnormal TA. Slope sign was observed in 5 AxA and in 1 carotid artery and 2 of them were false positive (atherosclerosis). Thirty-six (38.9%) patients had positive PET/CT. Positive DUS and PET/CT were present in 24 patients. Sixteen patients had a pathological DUS with a normal PET/CT and 12 patients had a positive PET/CT with normal DUS.

If TA and AxA were just considered, DUS had a sensitivity (Sn) of 73.1%, specificity (Sp) of 89.6%, a positive predictive value of 86% and negative of 82% with Area Under the Curve (AUC) 0.82 (95% CI 0.74-0.91) in ROC curve. When TA DUS was evaluated, we found a Sn 52% and Sp 97.9%. PET/CT showed a Sn 56.55 and a Sp 79.2% with an AUC 0.68 (95% CI 0.57 - 0.79).

Univariate analysis of clinical data is shown in Table 1. Independent risk factors according to logistic regression analysis were erythrocyte sedimentation rate (Exp (B) 1,01; p=0,038), vision loss (Exp (B) 2.93; p= 0.047), jaw claudication (Exp (B) 4.65; p= 0.014) and age (Exp (B) 1.07; p= 0.013).

Conclusion: TA and AxA DUS increase sensitivity with a slight decrease of specificity in GCA diagnosis. CA and VA DUS could be useful to increase diagnostic yield in GCA. The slope sign had a high rate of false positives (30%). PET/CT had less sensitivity and less specificity than DUS in all levels of clinical suspicion. Ageing, jaw claudication, loss of vision and increased ESR were found to be independent factors that can predict the presence of a pathological DUS.

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Table 1.

Comparison of clinical data according to Doppler ultrasound (DUS) results.

REFERENCES: NIL.

Acknowledgements: To my collegues, who encouraged me to go deeper in systemic diseases.

Disclosure of Interests: None declared.

  • Descriptive Studies
  • Diagnostic test
  • Imaging
  • Real-world evidence
  • Ultrasound

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    • Descriptive Studies
    • Diagnostic test
    • Imaging
    • Real-world evidence
    • Ultrasound

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    AB1320 DOPPLER ULTRASOUND IN GIANT CELL ARTERITIS: WHICH TERRITORIES SHOULD WE EXPLORE? A RETROSPECTIVE ANALYSIS OF A SINGLE CENTER EXPERIENCE (2024)

    FAQs

    What are the ultrasound findings in giant cell arteritis? ›

    Four pathological characteristics can be found by US in GCA: wall thickening (halo sign; Fig. 2), non-compressible arteries (compression sign; Fig. 3), stenosis and vessel occlusion. In GCA, cell infiltrates and oedema occur particularly in the media, potentially extending to the intima and the adventitia.

    What is the investigation of choice for giant cell arteritis? ›

    Biopsy. The best way to confirm a diagnosis of giant cell arteritis is by taking a small sample (biopsy) of the temporal artery. This artery is situated close to the skin just in front of your ears and continues up to your scalp.

    What is the best initial test for giant cell arteritis? ›

    Superficial temporal artery biopsy (TAB) is the criterion standard for diagnosing temporal arteritis. TAB should be obtained almost without exception in patients in whom GCA is suspected clinically.

    Which of the following is the most appropriate diagnostic study for definitively diagnosing giant cell arteritis? ›

    Patients suspected of having GCA should undergo a biopsy or color Doppler ultrasound (CDUS) of the temporal artery. Temporal artery biopsy: Traditionally, the gold standard diagnostic test for detecting GCA temporal artery biopsy has some limitations.

    Where is giant cell arteritis seen in the body? ›

    GCA commonly affects arteries in the head and neck. This condition can cause pain and tenderness in the soft part at the side of the head in between your eyes and ears, known as the temples. When the condition affects this part of the head it can be called temporal arteritis.

    What is the gold standard investigation for giant cell arteritis? ›

    Temporal artery biopsy is the 'gold standard' diagnostic test. It is the best way to diagnose giant cell arteritis and is very helpful with patients who do not respond to long-term treatment as expected.

    What is the imaging of choice for giant cell arteritis? ›

    US, PET, MRI, and/or CT may be used for detection of mural inflammation and/or luminal changes in extracranial arteries to support the diagnosis of large-vessel GCA.

    What are red flags for giant cell arteritis? ›

    Giant cell arteritis causes inflammation of certain arteries, especially those near the temples. The most common symptoms of giant cell arteritis are head pain and tenderness — often severe — that usually affects both temples. Head pain can progressively worsen, come and go, or subside temporarily.

    What is the life expectancy of someone with giant cell arteritis? ›

    Results 87 patients (51 females, 36 males) were included, their mean age at the time of GCA diagnosis was 73.9±8.4 and 75±8.1 years, respectively. The calculated mean life expectancy for this group of patients, from the time of diagnosis, was 14.1±6 years for females and 12±5.2 for males.

    What is the gold standard method of diagnosing temporal arteritis? ›

    In the ED, TAUS can be used to quickly rule out temporal arteritis while avoiding unindicated steroid treatment, which can cause serious morbidity in elderly patients. Temporal artery biopsy is the gold standard for diagnosing temporal arteritis.

    When should you suspect giant cell arteritis? ›

    The most common giant cell arteritis symptom is a throbbing, continuous headache on one or both sides of your forehead. Other temporal arteritis symptoms may include: Fatigue. Fever.

    What is the most feared complication of giant cell arteritis? ›

    Irreversible blindness, the most commonly feared complication, results from necrosis of the posterior ciliary branch of the ophthalmic artery and is usually preventable by early diagnosis and corticosteroid treatment.

    Is giant cell arteritis a disability? ›

    If the symptoms and impairments of your arteritis are severe enough to affect your ability to function or work, you may be eligible for long term disability insurance benefits.

    Is giant cell arteritis a terminal illness? ›

    Giant cell arteritis, also referred to as temporal arteritis, is a form of vasculitis which predominantly affects older people. It must be treated urgently, as it is associated with a significant risk of permanent visual loss, stroke, aneurysm and possible death.

    How accurate is ultrasound for temporal arteritis? ›

    Compared with clinical diagnosis made by the treating rheumatologist, temporal artery ultrasound had a sensitivity of 55% and specificity of 95.3%.

    What is the gold standard for diagnosing giant cell arteritis? ›

    Temporal artery biopsy has long been considered the gold standard for diagnosis of GCA. Although it is considered to be a minor invasive procedure, it is a procedure nonetheless.

    What are the advantages in diagnosis of giant cell arteritis by ultrasound? ›

    In GCA patients, ultrasound of temporal and axillary arteries has many advantages: it is widely available and it can be performed by the physician himself. The suspected diagnosis can be confirmed or excluded immediately. Ultrasound is not invasive and has no relevant side effects.

    What is the classic presentation of giant cell arteritis? ›

    Generally, signs and symptoms of giant cell arteritis include: Persistent, severe head pain, usually in your temple area. Scalp tenderness. Jaw pain when you chew or open your mouth wide.

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